Minmin gahaku7/3/2023 ![]() Genetic depletion of brain 5HT reveals a common molecular pathway mediating compulsivity and impulsivity. Neuroscience 122: 193–204.Īngoa-Pérez M, Kane MJ, Briggs DI, Sykes CE, Shah MM, Francescutti DM, Rosenberg DR, Thomas DM, Kuhn DM. Neurochemical and anatomical identification of fast- and slow-firing neurones in the rat dorsal raphe nucleus using juxtacellular labelling methods in vivo. Soc Cogn Affect Neurosci 7: 145–159.Īllers KA, Sharp T. Neural correlates of long-term intense romantic love. Ann N Y Acad Sci 1018: 46–57.Īcevedo BP, Aron A, Fisher HE, Brown LL. Anatomic and functional topography of the dorsal raphe nucleus. Minmin was a 17 year old suicide victim, highschool girl who jumped on the Seiya station, unlike Nakaikaka and Rorochans case where bullying is still up to debate, her case had confirmed years of school bullying and even household abuse, confirmed is definite abuse by her father and rumors are that there was even rape incidents, a very recent. ![]() Synapse 36: 21–34.Ībrams JK, Johnson PL, Hollis JH, Lowry CA. Electrophysiological and microdialysis studies. Dual control of dorsal raphe serotonergic neurons by GABA(B) receptors. Published by Cold Spring Harbor Laboratory Press.Ībellán MT, Jolas T, Aghajanian GK, Artigas F. Studies so far thus demonstrate the strong power of DRN neurons in reward signaling and at the same time invite additional efforts to dissect the roles and mechanisms of different DRN neuron types in various processes of reward-related behaviors. Electrophysiological recordings reveal that the activity of DRN neurons exhibits diverse behavioral correlates in reward-related tasks. Moreover, activation of DRN 5-HT neurons enhances reward waiting. Recent optogenetic stimulations demonstrate that transient activation of DRN neurons produces strong reinforcement signals that are carried out primarily by glutamate. Pharmacological studies indicate that 5-HT might be involved in modulating reward- or punishment-related behaviors. The DRN is commonly associated with serotonin (5-hydroxytryptamine 5-HT), but this nucleus also contains neurons of the neurotransmitter phenotypes of glutamate, GABA and dopamine. In this review, we will summarize anatomical, pharmacological, optogenetics, and electrophysiological studies on the functions and circuit mechanisms of DRN neurons in reward processing. However, the exact relationship between DRN neuronal activity and reward signaling has been elusive. ![]() The dorsal raphe nucleus (DRN) represents one of the most sensitive reward sites in the brain. ![]()
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